Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis

Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis.

Angiogenesis plays an important role in tumor progression. Several reports have demonstrated that a disintegrin and metalloproteinase with thrombospondin motifs1 (ADAMTS1) inhibited angiogenesis via multiple mechanisms. The aim of this study was to investigate the effect of ADAMTS1 on endothelial cells in vitro and on tumor growth with regard to angiogenesis in vivo. We examined the effects of ...

The tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis

Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium.

We previously showed that endothelial cells (EC) from the vasculature of human solid tumors have a decreased expression of intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 as compared with normal tissue EC. This effect is explained by EC exposure to angiogenic factors. It is known that upregulation of endothelial adhesion molecules (EAM) is a sign of EC activation in inflammatory responses...

Inhibition of Angiogenesis and Tumor Growth by a Synthetic

A laminin-derived synthetic peptide, Cys-Asp-Pro-Gly-Tyr-Ile-GlySer-Arg-NHz (CDPGYIGSR-NH2), containing an active site for cell binding inhibited both angiogenesis and solid tumor growth. It potently suppressed both embryonic angiogenesis of the chick chorioallantoic membrane and migration of vascular endothelial cells induced by a tumorconditioned medium but neither the in vitro proliferation ...

Inhibition of tumor growth by antibody to ADAMTS1 in mouse xenografts of breast cancer.

BACKGROUND A disintegrin and metalloproteinase with thrombospondin motifs-1 (ADAMTS1), a member of the ADAMTS family of proteases, is involved in the shedding of epidermal growth factor (EGF)-like ligands such as amphiregulin, which activate the EGF receptor. Since ADAMTS1 has been implicated in aggressive breast carcinogenesis, we examined potential antitumor effects of antibody to ADAMTS1 in ...